NMN, or nicotinamide mononucleotide, is a natural and essential precursor to NAD+. It is a critical compound that helps to produce the energy our bodies need to function optimally. NMN is found in trace amounts in certain foods and can be taken as a supplement to increase NAD+ levels.

What is NAD+?

NAD+ is an essential molecule in every living cell that helps to convert food into energy. It plays a critical role in keeping us healthy and is involved in many essential metabolic processes. As we age, our NAD+ levels naturally decline, leading to an increased risk of age-related diseases.

How Does NMN Help With NAD+?

When taken as a supplement, NMN helps to raise NAD+ levels in the body. By increasing NAD+ levels, NMN helps to improve energy production, regulate metabolism, and helps protect against age-related issues. Taking NMN as a supplement can help you unlock the full benefits of NAD+ and help you lead a healthier and more active lifestyle.

In numerous mouse models of disease and aging, NMN has demonstrated a wide array of remarkable effects, benefitting conditions ranging from diabetes to Alzheimer’s disease to ischemia.

Orally administered NMN is quickly synthesized into NAD+ in tissues in mice. NMN has been able to suppress age-associated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression. In mice bred to be diabetic or obese, NMN improved both the action and secretion of insulin.

NMN also protected the mouse heart from ischemia and/or reperfusion injury. It has restored skeletal muscle in aged mice, and slowed cognitive decline in a mouse model of Alzheimer’s disease, by improving the survival of neurons, improving energy metabolism, and reducing reactive oxygen species. It may help maintain the integrity of the blood brain barrier. NMN is likely a good candidate to suppress inflammaging—the increase in inflammation associated with aging—since studies show it lowers adipose tissue inflammation associated with age. In fact, older mice appear to be more responsive to NMN, in comparison with young mice.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/

To investigate the impact of NMN on weight, Bhasin and colleagues administered two daily doses of 1,000 mg of NMN to middle-aged and older overweight or obese adults for 28 days. This led to more than a 6 lb. decrease in body weight when compared to participants who did not receive NMN for 28 days. This finding suggests that NMN supplementation promotes metabolic benefits, as evidenced by a substantial indicator of metabolic health, namely body weight.

To investigate the impact of NMN on weight, Bhasin and colleagues administered two daily doses of 1,000 mg of NMN to middle-aged and older overweight or obese adults for 28 days. This led to more than a 6 lb. decrease in body weight when compared to participants who did not receive NMN for 28 days. This finding suggests that NMN supplementation promotes metabolic benefits, as evidenced by a substantial indicator of metabolic health, namely body weight.

https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgad027/7027634?redirectedFrom=fulltext&login=false